Related LncRNAs
ID lncRNA Name Disease Method Sample Expression pattern Dysfunction type Description PMID Source
EL0874 MIR100HG acute megakaryoblastic leukemia qPCR etc. blood, cell lines (CMK, Meg-01, K562, HT1080 and 293 T etc.) up-regulated N/A Here we report that lncRNAs MONC and MIR100HG are highly expressed in AMKL blasts. The transcripts were mainly localized in the nucleus and their expression correlated with the corresponding miRNA clusters. Knockdown of MONC or MIR100HG impeded leukemic growth of AMKL cell lines and primary patient samples. Our study reveals an unprecedented function of lncRNAs MONC and MIR100HG as regulators of hematopoiesis and oncogenes in the development of myeloid leukemia. 25027842 Lnc2Cancer
EL0883 MIR99AHG acute megakaryoblastic leukemia qPCR etc. blood, cell lines (CMK, Meg-01, K562, HT1080 and 293 T etc.) up-regulated N/A Here we report that lncRNAs MONC and MIR100HG are highly expressed in AMKL blasts. The transcripts were mainly localized in the nucleus and their expression correlated with the corresponding miRNA clusters. Knockdown of MONC or MIR100HG impeded leukemic growth of AMKL cell lines and primary patient samples. Our study reveals an unprecedented function of lncRNAs MONC and MIR100HG as regulators of hematopoiesis and oncogenes in the development of myeloid leukemia. 25027842 Lnc2Cancer